TechneScan® HDP Kit for the Preparation of Technetium Tc99m Oxidronate

TechneScan® HDP Kit for the Preparation of Technetium Tc99m Oxidronate
Mallinckrodt Inc.

TechneScan HDP Technetium Tc99m Oxidronate

NFPA

0
0 0

MSDS Name: TechneScan HDP Technetium Tc99m Oxidronate
Manufacturer Name: Mallinckrodt Inc.
Address:
2703 Wagner Place
Maryland Heights, MO 63043

Emergency Telephone Number: (314) 654-7860
CANUTEC: 613-996-6666
Business Phone: (888) 744-1414
Product Description:
TechneScan® HDP Kit for the Preparation of Technetium Tc99m Oxidronate
For information in North America, call: (888) 744-1414
Chemtrec: For emergencies in the US, call CHEMTREC: 800-424-9300
Manufacturer MSDS Revision Date: January 1, 2003
Synonyms:
Tc99m HDP; Tc99m Oxidronate
General Use:
Diagnostic imaging agent.

NFPA

Health: 0
Flammability: 0
Reactivity: 0
Other:
Chemical Name
Reconstituted Kit: Technetium-99m
CAS#
23288-60-0
SECTION 3 : HAZARDS IDENTIFICATION
Emergency Overview:
Read package insert prior to use! Promptly remove any contamination from skin, eyes, or clothing. Avoid all unnecessary exposure to the chemical substance.
Applies to All Ingredients:
Potential Health Effects:
The hazardous ingredients found in TechneScan HDP are skin and eye irritants, but due to the small quantities present in each container, no adverse health effects are expected to occur from exposure.
Eye Contact:
Not expected to be a health hazard.
Skin Contact:
Not expected to be a health hazard.
Inhalation:
Not expected to be a health hazard.
Ingestion:
Not expected to be a health hazard.
Chronic Health Effects:
Not expected to be a chronic health hazard.
Aggravation of Pre-Existing Conditions:
No information found.
SECTION 4 : FIRST AID MEASURES
Eye Contact:
Wash thoroughly with running water. Get medical advice if irritation develops.
Skin Contact:
Wash exposed area with soap and water. Get medical advice if irritation develops.
Inhalation:
Not expected to require first aid measures.
Ingestion:
Not expected to require first aid measures.
SECTION 5 : FIRE FIGHTING MEASURES
Fire:
Not considered to be a fire hazard.
Explosion:
Not considered to be an explosion hazard.
Extinguishing Media:
Use any means suitable for extinguishing surrounding fire.

Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.
SECTION 6 : ACCIDENTAL RELEASE MEASURES
Spill Cleanup Measures:
Collect non-radioactive spills and dispose of material as non-hazardous waste. For TechneScan® HDP Reconstituted with Sodium Pertechnetate Tc99m: If any loss or release of the radioactive contents occurs, notify your Radiation Safety Department and Mallinckrodt at (314) 654-7860. All cleanup operations should be performed according to the Standard Operating Procedures (SOPs) established for your facility and by the NRC or other applicable local, state or federal regulations.
SECTION 7 : HANDLING and STORAGE
Handling:
After reconstitution, handling time should be kept to a minimum, and appropriate shielding should be used. Handling devices such as syringe shields and tongs should be used.
Storage:
The drug should be stored at 15 deg C to 30 deg C both prior to and following reconstitution with Sodium Pertechnetate Tc-99m and discarded after eight (8) hours from the time of preparation. Storage and disposal of product should be controlled in a manner which is in compliance with the appropriate regulations of the government agency authorized to license the use of this radionuclide.
SECTION 8 : EXPOSURE CONTROLS, PERSONAL PROTECTION
Skin Protection Description:
Wear protective gloves and clean body-covering clothing.
Eye/Face Protection:
Safety glasses.
Respiratory Protection:
Not expected to require personal respirator usage.
Exposure Limits:
Airborne: None established.
SECTION 9 : PHYSICAL AND CHEMICAL PROPERTIES
Physical State/Appearance:
Small, dry, crystals clinging to inside of 6 mL glass vial.
Color:
White
Odor:
Odorless.
Boiling Point:
ca. 100 deg C (212 deg F) reconstituted
Melting Point:
ca. 0 deg C (32 deg F) Reconstituted
Solubility:
Soluble in water.
SECTION 10 : STABILITY AND REACTIVITY
Chemical Stability:
Stable under ordinary conditions of use and storage.
Incompatibilities with Other Materials:
No information found.
Hazardous Polymerization:
Will not occur.
Hazardous Decomposition Products:
When heated to decomposition, substance may emit oxides of carbon and corrosive fumes of hydrochloric acid.
SECTION 11 : TOXICOLOGICAL INFORMATION
Toxicological Paragraph:
For detailed toxicological information on specific components, write to the address listed in Section 1 - Attn: Regulatory Compliance Department.
SECTION 12 : ECOLOGICAL INFORMATION
Ecological Paragraph:
Because this product is intended for use by hospital or clinic patients, it is expected to be treated by standard wastewater treatment facilities with no adverse environmental impacts.
SECTION 13 : DISPOSAL CONSIDERATIONS
Waste Disposal:
TechneScan® HDP reconstituted with Sodium Pertechnetate Tc-99m is Radioactive Waste until the activity has decayed to nondetectable levels. Radioactive waste must be handled in accordance with procedures established by your Radiation Safety Officer, NRC and other applicable regulations.

If medical waste is involved, such as blood, blood products, or sharps, the waste must be handled as a Biohazard and disposed of accordingly.

If not radioactive or a biohazard, waste TechneScan HDP is considered non-hazardous. Consult local, state and federal regulations for proper disposal.
SECTION 14 : TRANSPORT INFORMATION
DOT Shipping Information:
Not regulated.
SECTION 15 : REGULATORY INFORMATION
Applies to all ingredients:
Section 302:
None
Section 304:
CERCLA Reportable Quantities: Tc-99m = 100 Ci (3.7 E 12 Bq)
Releases to air, land or water of these hazardous substances which exceed the Reportable Quantity (RQ) must be reported to the National Response Center at 800-424-8802.
Section 312 Hazard Category:
None.
Section 313 Toxic Release Form:
313 Toxic substances subject to annual release reporting requirements: None.
State:
California Proposition 65 Warning:
When this kit is reconstituted with radioactive material, this product contains a substance known to the State of California to cause cancer.
Canada WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.
Australia Hazchem Code: None allocated.
Australia Poison Control Code: None allocated.

RCRA Hazardous Waste Status: Non-hazardous (See Section 13 for additional details).
SECTION 16 : ADDITIONAL INFORMATION
NFPA:
Fire Hazard: 0
Health: 0
Reactivity: 0
MSDS Revision Date:
January 1, 2003

Revision Information: No changes.
MSDS Status: Revised in accordance with ANSI Guideline Z400.1-1998
Disclaimer:
Mallinckrodt provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. MALLINCKRODT MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.

Product Use: Diagnostic imaging agent

tyco/Healthcare
Mallinckrodt

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